There are alot of podcasts being produced out there. I've had trouble over the last couple years in finding good quality podcasts to listen to.
Here's a collection of the podcasts I listen to regularly:
Windows Weekly - A weekly look at all things Microsoft including Windows Vista, Office 2007, and Xbox from the foremost Windows expert in the world, Paul Thurrott of the Super Site for Windows
Security Now - Steve Gibson, the man who coined the term spyware and created the first anti-spyware program, creator of Spinrite and ShieldsUP, discusses the hot topics in security today with Leo Laporte.
Net at Nite - Live from Canada, California, and around the world... What's happening on the 'net right now? join Amber MacArthur and Leo Laporte live Sunday nights.
Futures in Biotech - Explore the world of genetics, cloning, protein folding, genome mapping, and more with the most important researchers in biotech. Hosted by Marc Pelletier and Leo Laporte.
FLOSS - We're not talking dentistry here; FLOSS all about Free Libre Open Source Software. Join hosts Chris DiBona and Leo Laporte every Friday as they talk with the most interesting and important people in the Open Source and Free Software community.
DotNetRocks! - An internet audio talk show for .NET developers. Carl Franklin and Richard Campbell interview .NET experts and other industry movers and shakers, and answer your .NET questions on the air, all for the purpose of bringing you insights into .NET technology, the marketplace, and the state of software development in general.
Hanselminutes - A weekly audio talk show with noted web developer and technologist Scott Hanselman and hosted by Carl Franklin. Scott discusses utilities and tools, gives practical how-to advice, and discusses ASP.NET or Windows issues and workarounds.
There are also a couple podcasts I listen to on occasion:
Polymorphic Podcast - Object oriented developement, architecture & best practices in .NET
ASP.NET Podcast - ASP.NET Podcast is geared towards the Microsoft .NET Framework and ASP.NET. The podcast is run by Wally McClure and Paul Glavich.
This Week In Law - Join Denise Howell and the TWiL panel, including Cathy Kirkman, Ernie Svenson, and John Palfrey as they discuss breaking issues in technology law including patents, copyrights, and more.
These podcasts generally provide me with just as much listening as I have time for. However, I am always looking for more good quality podcasts to add to my list. If you know of any others, please post them in the comments.
UPDATE 3/15: I also listen to TWIT (This Week In Tech) regularly. I don't know how I missed adding it to the list. I guess, the title of the post should now be "My Top 11 Tech Netcasts".